estrone n : a naturally occurring weak estrogenic hormone secreted by the mammalian ovary; synthesized (trade name Estronol) and used to treat estrogen deficiency [syn: oestrone, theelin, Estronol]
Estrone is one of the three estrogens, which also include estriol and estradiol. Estrone is the least prevalent of the three hormones, estradiol being prevalent almost always in a female body, estriol being prevalent primarily during pregnancy. Estrone is relevant to health and disease due to its conversion to estrone sulfate, a long-lived derivative of estrone. Estrone sulfate acts as a pool of estrone which can be converted as needed to the more active estradiol.
SynthesisEstrone is synthesized via aromatase from androstenedione, a derivative of progesterone. The conversion consists of the de-methylation of C-19 and the aromaticity of the 'A' ring. This reaction is similar to the conversion of testosterone to estradiol.
Image:Reaction-Androstendione-Estrone.png|Androstenedione converting to estrone. Image:Steroidogenesis.gif|Steroidogenesis
estrone in German: Estron
estrone in French: Estrone
estrone in Dutch: Estron
estrone in Japanese: エストロン
estrone in Portuguese: Estrona
estrone in Russian: Эстрон
estrone in Finnish: Estroni